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This Concept Map, created with IHMC CmapTools, has information related to: HIF-AKT-ROS, AMP/ATP ratio activate LKB1, AKT activate ? HIF-1a, NOX4 NADPH oxidase generate H2O2, Hypoxia inhibit PHD, mTOR induce protein synthesis, VEGF activate angiogenesis, AKT activate P70S6K1, PHD inhibit HIF-1a, H2O2 activate ? AKT, Hypoxia induce H2O2, Growth factors activate ERKs, EGFR generate ? H2O2, LKB1 activate MAPK, Rheb activate mTOR, Hypoxia inhibit FIH, energy depletion increase AMP/ATP ratio, EGF binds EGFR, PI3K activate AKT, TSC2/1 inhibit Rheb, Growth factors activate PI3K