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This Concept Map, created with IHMC CmapTools, has information related to: V15. Huntington Disease, Once # repeats gets to 36-40, expands considered Incomplete Penetrance, huntingtin is Ubiquitously expressed, Paternal Transmission althogh Maternal transmission does not result in expansion, 15. HUNTINGTON DISEASE phenotype Age of onset 35-44 y/o, Motor including Chorea (involuntary jerks), 15. HUNTINGTON DISEASE etiology Progressive neuro- degeerative disorder, Once # repeats gets to 36-40, expands on Paternal Transmission, New Mutation starts as Premutation, deleerious gain of function although Expression alone may be the culpri, CAG Expanion normally Repeated 10 to 26 times, Age of onset 35-44 y/o Survival after diagnosis 15 to 18 yrs, 35+ repeats younger patients have 60+ repeats, 35+ repeats causes deleerious gain of function, Paternal Transmission implies Younger onset when inherited from Dad, Progressive deterioration of Psychiatric, 35+ repeats can be Inherited from parent (97%), 35+ repeats note Once # repeats gets to 36-40, expands, 15. HUNTINGTON DISEASE mutation of HD Gene, 15. HUNTINGTON DISEASE phenotype Progressive deterioration, Progressive deterioration of Cognitive