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This Concept Map, created with IHMC CmapTools, has information related to: V03. Inherited Breast & Ovarian Cancer, Chemoprevention efficacy Who knows?, 50% risk of inheriting mutation but onset skewed due to Variable Expression, Risk for other cancers like Prostate, Loss of function of either BRCA1, Risk for other cancers like Colon, Risk for other cancers treatment options Mastectomy/ oophorectomy, BRCA2 encode ubiquitously expressed nuclear proteins, 50% risk of inheriting mutation but onset skewed due to Incomplete penetrance, 3-HEREDITARY BREAST & OVARIAN CANCER pathology Loss of function, Gene mutations in BRCA2, BRCA2 account for 70-80% of familial breast cancer, Colon though BRCA1, 3-HEREDITARY BREAST & OVARIAN CANCER etiology 3-10% of cancer, Loss of function of one allele causes loss of function in another hence Autosomal dominant, Two hit hypothesys that is Loss of function of one allele causes loss of function in another, 3-HEREDITARY BREAST & OVARIAN CANCER phenotype Risk for other cancers, BRCA1 encode ubiquitously expressed nuclear proteins, Maintain genomic integrity ie. Regulating DNA repair, Loss of function follows Two hit hypothesys, ubiquitously expressed nuclear proteins which Maintain genomic integrity