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This Concept Map, created with IHMC CmapTools, has information related to: inflammation, selectin receptors: P-,E- selectin binds selectin ligands on leukocytes: sialylated Lewis X, accumulation of leukocytes at site of infection w/ incr vascular permeability, cytokines: e.g. TNF, IL-1 act on endothelial cell receptors of blood vessls, accumulation of leukocytes at site of infection w/ attendant vascular dilation, selectin ligands on leukocytes: sialylated Lewis X slows WBCs leukocyte. starts "roll" into cells (transmigration), integrin ligand bind firmly to integrin receptor on leukocyte, deficiencies in integrins & selectins lead to defective leukocyte recruitment to site of infection & inc susceptblty to infections, endothelial cell receptors of blood vessls resulting in secretion of chemokines, inter cellular macrophage secretes cytokines: e.g. TNF, IL-1, chemokines stimulates motility leukocyte. starts "roll" into cells (transmigration), cytokines: e.g. TNF, IL-1 stimulate expression of ligands for integrin ligand, deficiencies in integrins & selectins called leukocyte adhesion deficiencies, endothelial cell receptors of blood vessls activates expression of L-selectin, inflammation is accumulation of leukocytes at site of infection, damaged tissue secretes cytokines: e.g. TNF, IL-1, endothelial cell receptors of blood vessls activates selectin receptors: P-,E- selectin