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This Concept Map, created with IHMC CmapTools, has information related to: antibacterial agents - beta-lactam antibiotics, bacitracin doesn't work w/ gram-neg bacteria, bacteria can produce beta-lactamases, specific PBP's (penicillin-binding proteins) in bacterial cell wall: transpeptidases, transglycosylases, carboxypeptidases catalyze building of chains and cross-links in peptidoglycan layer, beta-lactamases hydrolyzes beta-lactam ring, bacteria has specific PBP's (penicillin-binding proteins) in bacterial cell wall: transpeptidases, transglycosylases, carboxypeptidases, beta-lactamases include penicillinases cephalosporinases carbapenemases, beta-lactam ring deactivating beta-lactam antibiotics, beta-lactam antibiotics include Penicillins, polypeptides inc bacitracin, detergents hence best against gram-neg rods (have outer membrane), beta-lactamase inhibitors: clavulanic acid sulbactam tazobactam inhibit penicillinases cephalosporinases carbapenemases, beta-lactamase inhibitors: clavulanic acid sulbactam tazobactam inhibit beta-lactamases, glycopeptides e.g. vancomycin, vancomycin doesn't work w/ gram-neg bacteria, beta-lactam antibiotics sometimes used in conjuction with beta-lactamase inhibitors: clavulanic acid sulbactam tazobactam, beta-lactam antibiotics inc. polypeptides, specific PBP's (penicillin-binding proteins) in bacterial cell wall: transpeptidases, transglycosylases, carboxypeptidases inhibits formation of cross-links between peptidoglycan chains, beta-lactam antibiotics binds to specific PBP's (penicillin-binding proteins) in bacterial cell wall: transpeptidases, transglycosylases, carboxypeptidases, polypeptides inc polymyxins, Penicillins sometimes used in conjuction with beta-lactamase inhibitors: clavulanic acid sulbactam tazobactam