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This Concept Map, created with IHMC CmapTools, has information related to: MHC I and II, MHC I differences distinct subunit structures, MHC II deliver peptides originating in vesicular compartments which are detected by CD4 T-cells (or T-cells expressing CD4 molecules), cross presentation when APC's divert endocytosed antigens into MHC class I pathway, MHC I similarities sim. 3D structures, MHC II deliver peptides originating in vesicular compartments to cell surface, cross presentation is not well understood, MHC II similarities bind to self-proteins: histones ribosomal proteins heat shock proteins - hsp90 other, foreign peptides through TAP to ER, MHC I are very polymorphic, MHC I deliver peptides originating in cytosol which are detected by CD8 T-cells (or T-cells expressing CD8 molecules), foreign protein degraded by proteasomes foreign peptides, MHC I deliver peptides originating in cytosol to cell surface, foreign peptides associate in ER, MHC II expressed Lymphoid tissues: T-cells, B-cells, macrophages, other antigen- presenting cells, epi cells of thymus. on dendritic cells, macrophages, and B cells, MHC I expressed on all nucleated cells, MHC I similarities bind to self-proteins: histones ribosomal proteins heat shock proteins - hsp90 other, MHC II differences distinct subunit structures, foreign proteins/ antigens breakdown in endosome, MHC II similarities sim. 3D structures, MHC I associate in ER