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This Concept Map, created with IHMC CmapTools, has information related to: Antibiotics anti-DNA,RNA synth, Antibiotics DNA/RNA ∅ Synth Quinolones, Rifampin & Rafabutin binds to RNA poly rst - Δ subunit RnaPoly, G- intrinsic (↓uptake), Quinolones synthetic, inhib gyrase/ topoisomerase rst - ↓uptake, Δsite, expulsion, mod, Metronidazole cytotoxic DNA breaker Rx - amebiasis, giardiasis, anaerobic inf, Antibiotics DNA/RNA ∅ Synth Metronidazole, Metronidazole cytotoxic DNA breaker rst- ↓uptake, enzyme of cytotoxins, Rifampin & Rafabutin binds to RNA poly Rx- TB, aerobic G+ (staph, strep), Quinolones synthetic, inhib gyrase/ topoisomerase G- (pseudomas), som G+ rst- strept & entero ∴ coadmin w/∅cell wall Rx- Nalidixic - UTI (G-) ciprofloxacin, levofloxacin, gatofoxacin TB, strept., enteroc. Enteroc. G+ only w/ cellwall combo, Quinolones synthetic, inhib gyrase/ topoisomerase Streptomycin, neomycin, kenamycin, tobramycin amikacin netilmicin, Antibiotics DNA/RNA ∅ Synth Rifampin & Rafabutin