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This Concept Map, created with IHMC CmapTools, has information related to: Immune Reponse - Innate, Innate Repsonse ∅ host react 1. inherent spec. for micro 2. reg proteins on cells, Phagocytes Enter via Rolling, Stable Adhesion, Migration PMNs, IL-12 ↑ cytokine IL-12 (& from dendrites) (↑NK) T cell act. (2nd signal), Moncytes differentiate Macrophages survive long, Macrophages survive long Phagocytose kill w/ ROS, NO (some micro produce catalase), Macrophages survive long release cytokines IL-12, Innate Repsonse ↑ lymph flow ∴↑ antigen also, provide 2nd signal for act. of B&T cells Adaptive Response, Cytokines autocrine/paracrine IFN-γ - ↑ macrophag IL-12 - ↑NK, Innate Repsonse inflammation TNF IL-1 Chemokines, Macrophages survive long ↑ cytokine IL-12 (& from dendrites) (↑NK) T cell act. (2nd signal), Epithelial selectins ↑integrin ligands chemokines Physical, local antibiotics intraepithelial lympocytes, Innate Repsonse Components NK cels, Phagocytes Enter via Rolling, Stable Adhesion, Migration Leukocyte Adhesion Def. (integrins & selectins), IL-12 ↑ cytokine IL-12 (& from dendrites) (↑NK) NK cels, NK cels ↑ cytokine IFN-γ (↑ macrophag) Macrophages survive long, Innate Repsonse Components Phagocytes, Macrophages survive long release cytokines TNF & IL-1 (epithelial), ingest circulating microbes, die quick Phagocytose kill w/ ROS, NO (some micro produce catalase), Microbe recognize mol. patterns Innate Repsonse, Innate Repsonse Components Complement