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This Concept Map, created with IHMC CmapTools, has information related to: goodpastures disease, Crescentic GN Rapid progression to renal failure Diseases associated with crescentic GN --Post-infectious GN --Lupus --IgA --Goodpasture’s or anti-GBM Treatment usually requires steroid therapy with cytotoxic medications pathogenesis Breaks in GBM lead to release of fibrinogen into Bowman’s space and formation of fibrin there, leading to influx of macrophages into Bowman’s space and proliferation of epithelial cells – the crescent, Goodpasture's disease features 60 – 80% are men Clinical constellation of glomerulonephritis and pulmonary hemorrhage Two age groups: Young men 18-35 Older men&women 50–60, Crescentic GN Rapid progression to renal failure Diseases associated with crescentic GN --Post-infectious GN --Lupus --IgA --Goodpasture’s or anti-GBM Treatment usually requires steroid therapy with cytotoxic medications def A form of GN in which the majority of glomeruli contain an accumulation of cells within Bowman’s space. These cells are monocytes from the blood, epithelial cells and fibroblasts. ALWAYS associated with fibrin in Bowman’s space and usually with breaks in glomerular basement membranes. The pathologic counterpart of rapidly progressive GN (RPGN), Goodpasture's disease pathology focal or diffuse crescentic GN, Goodpasture's disease pathology Linear deposition of IgG along the glomerular basement membrane Fibrinogen in Bowman’s space No electron-dense deposits (same for anti-GBM disease) Lung shows pulmonary hemorrhage and focal linear IgG in alveolar septa Biopsy the kidney and do IF microscopy for diagnosis. Also look for anti-GBM in blood, focal or diffuse crescentic GN ???? Crescentic GN Rapid progression to renal failure Diseases associated with crescentic GN --Post-infectious GN --Lupus --IgA --Goodpasture’s or anti-GBM Treatment usually requires steroid therapy with cytotoxic medications, Goodpasture's disease presentation Crescentic GN Pulmonary hemorrhage -Absent in anti-GBM disease, Goodpasture's disease pathogenesis ????