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This Concept Map, created with IHMC CmapTools, has information related to: L-Expanded, Fever ???? Pyrogens fever producing substances, Chemical Barriers types Low pH, Chemical Barriers types Lysozyme, B-Cells antibodies Constant Region determines destinatoin (body location) of antibody and functional class (IgM, IgG), major histocompatibility complex (MHC) also called human leukocyte antigens (HLAs), Cytokines small signaling molecules released by immune system cells cell communication types Chemokines relased to guide lympohcytes to lymph nodes and to infection sites, recognizes/binds to the MHC-II/antigen complex on B-cels and activates B-cells secretes IL-2/4 to activate multipication The B-cells multiplate and differentate into...., recognize non-self cells secrete Perforins drill holes in target cells, Natural Killer Cells help recognize non-self cells, suppress activation of immune system through IL-10 shuts down after successful handeling not functioning properly IPEX syndrome Multiple autoimmune disorders Often fatal w/i 1st year, Aquired Immune Response type Humoral (Antibody-mediated) Immunte Response - depends upon action of B-cells - production of antibodies, remember what looked like production of IgG Major circulating antibody (80%) Appears 24-48 hrs after Maternal crosses over to placenta to provide immunity to fetus until ~6 months, B-Cells Primary antibody response B cells are activated, plasma cells produce antibodies, memory B cells porduced IgM appears first, replaced by IgG, Phagocytes cells Neutrophils, Phagocyosis occurs through Macrophages, Fever ???? abnormally high body temperature, Innate Immunity Second Line Defenses Phagocyosis, Lymphocytes cells T-Cells, Chemical Barriers types Lactoferrin, Leukocytes White Blood Cells (WBC) types Other