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This Concept Map, created with IHMC CmapTools, has information related to: Folate-B12, Iron, HMP shunt, deficiency causes microcytic anemia, Tetrahydrofolate (FH4) have 4 forms Formyl, G6PD (glucose 6-phosphate dehydrogenase) deficiency reduces supply of, megaloblastic anemia manifests as cytoplasm gets bigger, nucleus lags, Folate structure consists of PABA, amino acid metabolism to make serine, oxidative/irreversible reactions where G6P, methotrexate (MTX) stops thymidine biosynthesis, Ribulose-5-P transketolases (vitamin B1) F6P, NADPH reduces H2O2, B12 (cobalamin) deficiency, to produce NADPH which protects membrane lipids, Folic acid/B12 deficiency causes homocysteinuria, B12 (cobalamin) required for de novo purine synthesis, biliverdin changed to bilirubin, B12 deficiency via Methyl-Trap Hypothesis, reduced GSH which causes increased, deficiency causes reduced GSH, phagocytic respiratory burst defects categorized as chronic granulomatous disease (CGD), G6PD (glucose 6-phosphate dehydrogenase) deficiency blocks