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This Concept Map, created with IHMC CmapTools, has information related to: Reward Pathway, Mesolimbic Dopamine System Located in the Median Forebain Bundle, Mesolimbic Dopamine System Consists of VTA, Stimulants: Act on NA to increase DA THC ????, Stimulants: Act on NA to increase DA Amphetamine Travel into cell via DAT. Displaces DA from vesicles. DA leaks presynaptic terminal & leaks from the cell into cleft via DAT., Mesolimbic Dopamine System Consists of Nucleus Accumbens, Natural Reward Increase DA Mesolimbic Dopamine System, Stimulants: Act on NA to increase DA Cocaine Regulates DA in Synaptic Cleft Blocks DA reuptake via DAT, Drugs What do they do? Stimulants: Act on NA to increase DA, Mesolimbic Dopamine System A.K.A. Reward Pathway, VTA Sends DA to Nucleus Accumbens, Drugs Can lead to Addiction: compulsive behavior reinforced by reward., Stimulants: Act on NA to increase DA Opiates Indirect mechanism: Decrease GABA inhibition of DA release, Median Forebain Bundle discovered by Olds and Milner, 1954, Drugs Increase DA Mesolimbic Dopamine System, Stimulants: Act on NA to increase DA Increase DA Mesolimbic Dopamine System