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This Concept Map, created with IHMC CmapTools, has information related to: platlet adhesion and aggregation (Flan), aggregation basically bridging, megakaryocyte cytoplasm lack DNA, higher affinity state through disrupting cytoplasmic tails of GPIIb-IIa alpha-IIb-beta-3, dense granules are effector molecules, IIa thrombin cleaves circulating fibrinogen, thrombocytes do not adhere to endothelium, higher affinity state promotes binding of extracellular cellular ligands, endothelium exposes thrombocytes, factor III thromboplastin cooperativley activate coagulation pathway, alpha-2-beta-1 (GPIa-IIa) receptor bind collagen, GPIIb-IIa alpha-IIb-beta-3 is an integrin, TxA2 Thromboxane A2 bind to specific platlet membrane receptors, transmembrane signalling folowed by intracellular signalling, granule release facilitate platlet recruitment, trauma to endothelium, thrombocytes lack nucleus, polymerized forms permanet plug, subendothelial matrix which has collagen, thrombocytes to subendothelial matrix, alpha-2-beta-1 (GPIa-IIa) receptor allows GPVI