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This Concept Map, created with IHMC CmapTools, has information related to: RitaArthurCaseB3, accumuluation of sensitizing agents activates via positive feedback glial cells, DMARDs inhibits TNFalpha, plasma cells which produces IgM antibodies, Mature Helper CD4 T Cell expresses RANKL, bone leads to bone erosion, Th2 secretes IL-2, cell proliferation specifcally immune cells, Patient, Rita Arthur follows vegetarian diet, accumuluation of sensitizing agents leads to activation of protein kinase signaling cascade, anti-TNFalpha therapy reduces vasodilation, HLA gene encodes for HLA molecule, IL-2 activates CD8 Tcells, decreased threshold of activation leading to peripheral sensitization, protein kinase signal cascade which decreases threshold of activation, silent nociceptors contributes to hyperalgesia, synoviocytes in synovia, primary afferent neuron prolonged stimulation leads to central senstization, Th1 secretes INFgamma, hyaluronic acid which contributes to low pH/ acidic solution, leukotrienes recruits neutrophils