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This Concept Map, created with IHMC CmapTools, has information related to: Winters, Amy Winters cell line analyzed via PCR for presence of Results: BCR/ABL to ABL ratio 0.000125, Amy Winters Healthy NOW Going TO DISNEYWORLD, ABL gene Activates cell cycle proteins BCR/ABL gene fusion, LOOKS THE SAME! CML Leukemia Blood Smear Diminished levels of mature WBC's, p210 fusion protein is a constitutively active tyrosine kinase, rapid proliferation of myeloid progenitors leads to Increase Levels of Immature WBC's, IL-1 and TNF are pyrogenic cytokines, LOOKS THE SAME! Amy Winter's Blood Smear presence of immature precursors of the myelocytic cell line, Histology CML Leukemia Blood Smear Diminished levels of mature WBC's, Tyrosine Kinase Inhibitor acts to Inhibit uncontrolled proliferation of cells, Histology Amy Winter's Blood Smear disappearance of fat and abundance of dark nuclei., macrophages, granulcyties, lymphocytes Secrete IL-1 and TNF, Histology CML Leukemia Blood Smear Increase Levels of Immature WBC's, RAS/MAPK signaling resulting in rapid proliferation of myeloid progenitors, LOOKS THE SAME! CML Leukemia Blood Smear Increase Levels of Immature WBC's, Dasatinib is a Tyrosine Kinase Inhibitor, Results: BCR/ABL to ABL ratio 0.000125 confirming BCR/ABL gene fusion, LOOKS THE SAME! Amy Winter's Blood Smear abundance of segmented and band neutrophils as well as the presence of immature precursors of the myelocytic cell line, Histology . Amy Winters, LOOKS THE SAME! Amy Winter's Blood Smear disappearance of fat and abundance of dark nuclei.