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This Concept Map, created with IHMC CmapTools, has information related to: GROUP 2 CONCEPT MAP DRAFT (latest), diseases occur because of increase in the number of pathogens, MICROBIAL COMPOSITION of Clinically healthy gingiva, Eubacterium E. brachy, Initial lesion presents with Collagen depletion, 5 Stages start with Pellicle Formation, TNF-a which causes destruction of ECM, mechanically removed through toothbrusing, Reversible Adhesion ???? of microorganisms, lymphocytes such as B cells, Destruction of periodontal fibers leading to Alveolar bone loss, TNF-a which causes bone resorption, there is formation and accumulation of dental biofilm undergoes 5 Stages, Histologically presents with No inflammatory infiltrate, chemical mediators specifically high levels of IL-1B, inmlammatory infiltrate at the site of infection in the oral epithelium, host cells including leukocytes, balance between the bacterial challenge of the biofilm, 5 Stages may progress into build up of plaque, sulcular area causing possible lacerations, Acute Bacterial Challenge Phase wherein the entry of bacterial components