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This Concept Map, created with IHMC CmapTools, has information related to: Problems with Hemoglobin, Release of O2 to MB Results in Anemia, Favor Oxy form Leads to Higher 02 Affinity, Residue B10 Wild type LEU, Higher 02 Affinity Impedes Release of O2 to MB, Stabilize Deoxy Mutants Favor Oxy form, VAL Swap ASP, Residue B10 Mutant PRO, Non-polar pocket Mutant Pocket becomes polar, Hb Bristol Can be Fatal, HEMOGLOBIN DEFECTS May affect Functional Areas, BPG Site Should bind to Positive site, ARG HC 3a1 to ASP H9a2, Functional Areas Include C-terminal portions, Quaternary Structure Can be Alpha1 Beta1, Salt Bridges ex. ARG HC 3a1, Residue E11 Mutant ASP, Hb Bristol Problem Residue E11, Pocket becomes polar As in SER, Electrostatic Interactions ie. Salt Bridges, Pocket becomes polar Ex. Hb Hammersmith