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This Concept Map, created with IHMC CmapTools, has information related to: Sickle Cell Anemia, A3 Beta 6 GLU With VAL, SICKLE CELL DISEASE Treatment No cure yet, Lower Density Due to Low Hb, SS reticulcytes Bind to Fibronectin, Lag time (Td) Inversely related to Concentration of intercellular hemoglobin, Hydroxyurea Cons May cause cancer in the long run, SICKLE CELL DISEASE Pathology Single AA Substition, Hydroxyurea Pros Non-toxic, Degree of Deoxigination Note... Faster deoxigination prevents sickling, SS red cells= broad density See increases in Higher Density, Polymerization Inhibited by Hemoglobin F, SS red cells= broad density See increases in Lower Density, Sickling Makes blood Insoluble, Vascular Endothelium Studies show SS cells are stickier, SICKLE CELL DISEASE Kinetics Dynamic, Single AA Substition Replace A3 Beta 6 GLU, Lag time (Td) Note Usually transit times < Td, Hydrophobic Interaction Whereby One Beta subunit interacts with a Beta subunit of a different Hb, Ca++ activated K+ effusion (Gardos) Occurrs when Membrane is damaged, Ca++ activated K+ effusion (Gardos) Inhibited by Clotrimazole