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This Concept Map, created with IHMC CmapTools, has information related to: 02l. Tuberculosis, Acid fast smears 50-80% sensitive compared to cultures, Pulmonary either Primary infection, Delay in T-cell response explains Takes 6 to 8 weeks for detectable immunity, Extrapulmonary (15% of cases) occurs by Lymphohematogenous, Secondary infection (reactivation) Due to change in host/parasite balance, TUBERCULOSIS LIPIDS, Waxy, intracellular, HIV, Reactivation, balance, BCG, resistance Ref: Pages 777-792; Microcard 57 Lower repiratory tract infection host immune response KEY IS BALANCE!, Extrapulmonary (15% of cases) either Tuberculous meningitis (rupture of lesion), LIPIDS Not heat resistant, Secondary infection (reactivation) Infection often liquefies, spreads, Org grows unchecked until cell mediated response develops host immune response Death usually due to excessive lung damage (suffocation), All forms may reactivate Organism can stay metabpolically inactive for years at a time (no one knows why), Mycolic acids (cord factor) Target of INH, Transmission factors Droplet nuclei, TUBERCULOSIS LIPIDS, Waxy, intracellular, HIV, Reactivation, balance, BCG, resistance Ref: Pages 777-792; Microcard 57 Lower repiratory tract infection bug Mycobacerium tuberculosis High iron requirement, BCG vaccine Not a great vaccine (also inteferes with skin test), May have incomplete killing Granulomas, Secondary infection (reactivation) 80% of adult TB, Cultures May take 3-4 weeks to get an answer, TUBERCULOSIS LIPIDS, Waxy, intracellular, HIV, Reactivation, balance, BCG, resistance Ref: Pages 777-792; Microcard 57 Lower repiratory tract infection presentation Pulmonary, 50-80% sensitive compared to cultures Cultures