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This Concept Map, created with IHMC CmapTools, has information related to: 03c. Epstein-Barr Virus, EPSTEIN-BARR VIRUS Mono, Burkitt's lymphoma, kissing disease, atypical lymphocytes, B-cells, splenic rupture Ref: Pages 823-826; Microcard 106 Multisystem viral infection signs Healthy people, especially teens, Healthy people, especially teens see Abrupt sore throat, EPSTEIN-BARR VIRUS Mono, Burkitt's lymphoma, kissing disease, atypical lymphocytes, B-cells, splenic rupture Ref: Pages 823-826; Microcard 106 Multisystem viral infection prevention Vaccines are being tested, EPSTEIN-BARR VIRUS Mono, Burkitt's lymphoma, kissing disease, atypical lymphocytes, B-cells, splenic rupture Ref: Pages 823-826; Microcard 106 Multisystem viral infection epidemiology Infection in early childhood is less severe, Asain pop at risk for special complication Nasopharyngeal carcinoma in chinese population, First infects oropharyngeal epithelial cells then Affects B-cells (CD21 - a C3b complement receptor), Other complications incl Oral hairy cell leukemia, Atypical lymphocytes Atypical lymphocytes -Larger, angrier looking, EPSTEIN-BARR VIRUS Mono, Burkitt's lymphoma, kissing disease, atypical lymphocytes, B-cells, splenic rupture Ref: Pages 823-826; Microcard 106 Multisystem viral infection bug First infects oropharyngeal epithelial cells, Healthy people, especially teens see Greyish membrane, tonsillar elgargement, Immunocompromised see Other complications, Activation of T-cells they are Atypical lymphocytes -Larger, angrier looking, EPSTEIN-BARR VIRUS Mono, Burkitt's lymphoma, kissing disease, atypical lymphocytes, B-cells, splenic rupture Ref: Pages 823-826; Microcard 106 Multisystem viral infection treatment High doses of acyclovir slightly helps, EPSTEIN-BARR VIRUS Mono, Burkitt's lymphoma, kissing disease, atypical lymphocytes, B-cells, splenic rupture Ref: Pages 823-826; Microcard 106 Multisystem viral infection bug Requires intimate contact (saliva), Affects B-cells (CD21 - a C3b complement receptor) however B-cell response is NOT important for clearing disease, Other complications incl Lymphocytic pneumonia in HIV, Abrupt sore throat Greyish membrane, tonsillar elgargement, Atypical lymphocytes supplanted by Serology -Can tell if px suspectible -Current/recent/past infx, Healthy people, especially teens see Several weeks of severe fatigue, EPSTEIN-BARR VIRUS Mono, Burkitt's lymphoma, kissing disease, atypical lymphocytes, B-cells, splenic rupture Ref: Pages 823-826; Microcard 106 Multisystem viral infection diagnosis Serology -Can tell if px suspectible -Current/recent/past infx