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This Concept Map, created with IHMC CmapTools, has information related to: Sickle Cell Anemia, SICKLE CELL DISEASE Treatment No cure yet, A3 Beta 6 GLU With VAL, Lag time (Td) Inversely related to Concentration of intercellular hemoglobin, SS reticulcytes Bind to Fibronectin, Lower Density Due to Low Hb, Hydroxyurea Cons May cause cancer in the long run, Hydroxyurea Pros Non-toxic, SICKLE CELL DISEASE Pathology Single AA Substition, Degree of Deoxigination Note... Faster deoxigination prevents sickling, SS red cells= broad density See increases in Higher Density, SS red cells= broad density See increases in Lower Density, Polymerization Inhibited by Hemoglobin F, Sickling Makes blood Insoluble, Single AA Substition Replace A3 Beta 6 GLU, SICKLE CELL DISEASE Kinetics Dynamic, Vascular Endothelium Studies show SS cells are stickier, Lag time (Td) Note Usually transit times < Td, Ca++ activated K+ effusion (Gardos) Occurrs when Membrane is damaged, Hydrophobic Interaction Whereby One Beta subunit interacts with a Beta subunit of a different Hb, Clotrimazole Treatment Option Can be given as a drug