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This Concept Map, created with IHMC CmapTools, has information related to: 05. One carbon metabolism, Glycine or alterntely... Deaminated, S-adenosylmethionine (SAM) Once donated, left over is S-adenosyl homocystein, Folic Acid made by Micro organisms, 5,10 Methylene THF Synthesize from Glycine, N5 can be in Multiple oxication states, Intercoversion requires B6, histidine degradation ultimately gltamate, High Levels especially when Given high levels of HIS, B12 Deficiency Methyl trap, Micro organisms in the presence of p-aminobenzoic acid (PABA), Tetrahydrofolate (THF) properties Interconvertable, homocysteine note... used in synthesis of Cysteine, CBS Enzyme deficiency results in homocystinuria (too much homocysteine), Cancer note Toxic to ALL cells (inhibits pyrmidine synthesis), Cofactors either NADP, Tetrahydrofolate (THF) Source of carbons Serine, dihydrofolate Reductase (DFR) inhibited by Methotrexate, 5,10 Methenyl THF which can be converted to 5,10 Methylene THF, Tetrahydrofolate (THF) Source of carbons Glycine, Tetrahydrofolate (THF) Source of carbons Formate