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This Concept Map, created with IHMC CmapTools, has information related to: 17. Prostaglandins, PROSTAGLANDINS synthesis starts with 20 Carbon F.A., Platelets uses cox I, cAMP problem Viox (strong knockout off cox II) implies less production of cAMP, Cyclooxygnase (cox) makes intermediate PGG2, cAMP which inhibits Clumping, cox II inhibited by Celebrex, Endothelial Cells (see CaTOS Block 2) produce cAMP, Eicosanoids include PG= Prostaglandin, PROSTAGLANDINS wide function Alter CAMP levels, cAMP which inhibits Thromboxane A2 (TXA2), 20 Carbon F.A. usually Arachidonic acid, PG= Prostaglandin Third letter= substrate (ex. PGE), Leukotrienes derived from enzyme Lipoxygenases, Eicosanoids include TX = Thromboxane, PROSTAGLANDINS structure 20 Carbon unsat. F.A. derivitaves, 20 Carbon F.A. note Fish oils help here, Different products based on location ie Endothelial Cells (see CaTOS Block 2), PG= Prostaglandin Subscript = # of double bonds, Endothelial Cells (see CaTOS Block 2) uses cox II, Eicosanoids include Derivatives of arachadonic acid