Warning:
JavaScript is turned OFF. None of the links on this page will work until it is reactivated.
If you need help turning JavaScript On, click here.
This Concept Map, created with IHMC CmapTools, has information related to: 29e. Renal Physiology, Extrusion across basolateral membrane relies on Na+/K+ ATP pumps, Capillary loops in parallel which Keeps hydrostatic pressure constant, Na concrentration gradient -Not active transport Na+ uptake can be Coupled to other exchange mechanisms -Like Cl-/HCO3- exchanger in apical membrane -Coupled to paracellular diffusion ex: reabsorption of Cl-, Glucose reabsorption -Proximal tubes: 1 Na+ needed to get glucose in (SGLT2) -Distal tubule: Needs 2 Na+ per glucose (SGLT1) -Glucose leaves cells via GLUT transporter see -Insulin signaling (MBM-3), -Conductivity -Area note Increases upon -Dialation of afferent arteriole -Constriction of efferent arteriole Opposite decreases GFR, Loop of Henle specifically Thick Ascending loop (TALH) -Actively absorbs Cl- -Doesn't absorb water so filtrate becomes hypotonic, Na concrentration gradient -Not active transport Na+ uptake can be Used to transport solutes against their gradient (Cotransport), Glomerular filtration rate (GFR) -Changes filtration fraction determined by -Conductivity -Area, RENAL PHYSIOLOGY can be split regionally into Loop of Henle, Proximal tubules -Reabsorb 2/3 of solutes and water -Leaky epithelium -Extensive amplification of apical basolateral membrane primary driving force Na+ transport, RENAL PHYSIOLOGY in general goverened by Starling's law -Sys that fluid flow is initially out of capillary (filtration) but reverses at end of capillary (absorption), Glomuerular filtration -Structre determines which things pass into filtrate -Site of filtration -Lots of things get filtered out of blood has Capillary loops in parallel, RENAL PHYSIOLOGY can be split regionally into Glomuerular filtration -Structre determines which things pass into filtrate -Site of filtration -Lots of things get filtered out of blood, Distal tubules -Have more tight junctions -Are less leaky -Na:Cl cotransporters inhibited by thiazide influenced by Aldosterone, Distal tubules -Have more tight junctions -Are less leaky -Na:Cl cotransporters inhibited by thiazide primary driving force Na+ transport, Na+/K+ ATP pumps establishes Na concrentration gradient -Not active transport, Glucose reabsorption -Proximal tubes: 1 Na+ needed to get glucose in (SGLT2) -Distal tubule: Needs 2 Na+ per glucose (SGLT1) -Glucose leaves cells via GLUT transporter in the end Urine should be free of glucose, - Na:K:2Cl- Cotransporters - K+ channels (spits K+ into lumen) note Still relies on Na+/K+ pumps to establish gradient, Urinary system Mostly talking about Kidney, RENAL PHYSIOLOGY can be split regionally into Distal tubules -Have more tight junctions -Are less leaky -Na:Cl cotransporters inhibited by thiazide