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This Concept Map, created with IHMC CmapTools, has information related to: 28. Guanylate Cyclase, Nitrous Oxide needed for Erection (CaTOS-3), Nitrous Oxide activates Guanylate cyclase, Cyclic GMP (cGMP) inhibited by Phosphodiesterase, Guanylate cyclase which Converts GTP, N.O. binding domain for Nitrous Oxide, Three domains including Extracellular doman, Nitrous Oxide clinically can use Nitroglycerin, Cell surface (particulate) binds ligand Atrial Natriuretic Peptide, Atrial Natriuretic Peptide blocks Release of angiotensin (CaTOS-Block3), Phosphodiesterase which in turn can be inhibited by Viagra, Nitrous Oxide note Is not made in same cell as GC, Nitroglycerin for Smooth muscle relaxation, Atrial Natriuretic Peptide in Heart, Cytosol (soluble) has Two domains, Guanylate Cyclase Reference Pages 632-633, Extracellular doman binds Atrial Natriuretic Peptide, Guanylate Cyclase two types (by location) Cell surface (particulate), Cytosol (soluble) binding ligand Nitrous Oxide, Protein Kinase G causes Phosphorylation of proteins, N.O. binding domain has Heme group