Group 2 - Case 3 What ifs Large Animal Ð Older animal Ð Hematogenous 1. Signs and symptoms Ð lameness, local heat pain and swelling, anorexia and depression (same as foal); possible leukocytosis with degenerative left shift; bony destruction on radiographs 10-14 days after onset of infection; positive culture from bone likely; progression of bone destruction visible radiographically 2. Management plan - culture and sensitivity; local (drill holes into infected bone for infusion) and aggressive systemic antibiotic treatment (6 weeks); manual removal of any dead bone; lavage with sterile saline 3. Difference from case 3 Ð less likely to occur in mature animal due to differences in blood supply to bone (physes are closed); curratage less risky since growth plate disruption isnÕt a factor; possible iatrogenic etiologies more likely (surgery creating hematoma pocket for bacterial growth and opportunity to seed bone); mature animal would have a more developed immune system discouraging such infections;