Case 3: Prognosis The prognosis in this case is guarded, but it is better since only one joint is involved. With early aggressive treatment with antibiotics and with joint lavage, the prognosis is improved. The prognosis depends on just how much bone lysis and articular damage has already occurred. Through observation of the radiographs, it is evident that bone lysis has already occurred in the epiphysis, which is evidence of a worse prognosis. Bone fragments will have to be surgically removed if they are dead or their vascular supply is diminished.