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This Concept Map, created with IHMC CmapTools, has information related to: Ibuprofen and the Pain Pathway, ARACHIDONIC ACID which stimulates production of Cyclo-oxygenase (COX) ENZYMES, Renal & Hepatic Problems Blood Disorders Gastrointestinal Problems Diminishes effects of Anti Hypertensive Drugs Asthma Increases Toxicity of 'Methotrexate' Ibuprofen should be Taken after food and not on an empty stomach, Cyclo-oxygenase (COX) ENZYMES ???? COX 1, Cause of Pain Mechanical - ie trapped finger Chemical - i.e. chemical spillage Temperature - i.e. burn Tissue damage occurs and causes release of chemicals - i.e.Bradykinin Histamine and ARACHIDONIC ACID, COX 2 IBUPROFEN REDUCES/INHIBITS 'COX 2' Enzyme which Stops the PROSTAGLANDIN HORMONE being released which is specifically involved with INFLAMMATION & PAIN, Stops the PROSTAGLANDIN HORMONE being released which is specifically involved in GUT, KIDNEY & PLATELET FUNCTION This can result in unwanted (side effects) Renal & Hepatic Problems Blood Disorders Gastrointestinal Problems Diminishes effects of Anti Hypertensive Drugs Asthma Increases Toxicity of 'Methotrexate', COX 1 IBUPROFEN REDUCES/INHIBITS 'COX 1' Enzyme which Stops the PROSTAGLANDIN HORMONE being released which is specifically involved in GUT, KIDNEY & PLATELET FUNCTION, COX 1 relates to Gut, Kidney & Platelet activation, Cyclo-oxygenase (COX) ENZYMES ???? COX 2, Stops the PROSTAGLANDIN HORMONE being released which is specifically involved with INFLAMMATION & PAIN this results in PAIN RELIEF & REDUCTION IN INFLAMMATION, COX 2 relates to Inflammation & Pain