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This Concept Map, created with IHMC CmapTools, has information related to: Section 4.1, nonbiological agents such as radiation, retroviral provirus as discussed in Section 3.7, Katsusaburo Yamagiwa which is further discussed in Section 2.9, nonbiological agents can induce cancer, cancer aka tumor development, germ-line cells caused by integration of retroviral provirus, endogenous retroviruses are usually latent, Katsusaburo Yamagiwa discovered that nonbiological agents, cancer without viral infectious spread, endogenous retroviruses were found to cause cancer, endogenous retroviruses e.g. HERV-K, latent but may be expressed to release infectious retroviral particles, Katsusaburo Yamagiwa which is further discussed in Section 2.8, infectious retroviral particles thus causing tumor development, nonbiological agents such as Organic chemicals, endogenous retroviruses which are relics of infections in germ-line cells