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This Concept Map, created with IHMC CmapTools, has information related to: Section 4.4, oncoprotein which is further discussed in Chapter 5, reading frame thus can still form an oncoprotein, genetic changes e.g. point mutation, repression which may affect mitogenic growth factors, genetic changes which induces transformation, mitogenic growth factors which is further discussed in Chapter 5, protein structure such as presence of an oncoprotein, genetic changes that affect protein expression, constitutive which may affect mitogenic growth factors, transcriptional promoter e.g. constitutive, protein expression due to abnormal control by a transcriptional promoter, proto-oncogenes are activated by genetic changes, point mutation which allows for normal reading frame, transcriptional promoter e.g. repression, genetic changes that affect protein structure, oncoprotein which is further discussed in Chapter 6