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This Concept Map, created with IHMC CmapTools, has information related to: Section 4.5, gene amplification e.g. N-myc, growth-promoting powers which is discussed in Chapter 8, gene amplification appears as homogeneously staining regions, physiological regulation leading to high constitutive levels, N-myc which contain potent growth-promoting powers, v-myc oncogene via gene amplification, chromosomal translocation contains a fusion site called a breakpoint, chromosomal translocation e.g. that present in Burkitt's lymphoma, chromosomal translocation which disrupt normal physiological regulation, v-myc oncogene via chromosomal translocation, gene amplification which disrupt normal physiological regulation, c-myc proto-oncogene is activated to become v-myc oncogene, breakpoint which on the other side contains transcription-promoting sites, v-myc oncogene via provirus integration, N-myc causing childhood neuroblastomas, transcription-promoting sites which may express one of three immunoglobulins, chromosomal translocation is reciprocal, high constitutive levels of protein expression, gene amplification as discussed in Section 4.3, provirus integration which disrupt normal physiological regulation