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This Concept Map, created with IHMC CmapTools, has information related to: Chapter 2 - Revised, Carcinogens cause Human cancers, Tumor cells that are Malignant, Distant sites aka Metastases, Epithelial cells are derived from primitive cell layers called Ectoderm, Endothelial cells give rise to cancer called Angiosarcoma, Monoclonal are Common, Specialized cell types e.g. Epithelial cells, Anaplastic tumors are less histologically Advanced, Carcinogens are not necessarily Mutagens, Myelomas express a specific set of genes encoding Immunoglobulin, Carcinomas derived from secretory cells are called Adenocarcinomas, Benign may cause Clinical problems, Pathogensis aka Disease development, Connective tissue cells are derived from Mesoderm, Specialized cell types e.g. Cells in nervous system, Polyclonal are derived from Several different tumor cells, Carcinogenic can induce Cancers, Minor groups that include Melanomas, Extracellular matrix e.g. Basement membrane, Epithelial- mesenchymal transition may accompany and enable Invasion