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This Concept Map, created with IHMC CmapTools, has information related to: Section 6-12, Patched inhibits Smoothened, 150 target genes including myc gene, Nuclear factor-κB (NF-κB) activates the expression of 150 target genes, Notch when truncated to only the cytosolic form is an Oncoprotein, Transforming growth factor-β (TGF-β) is discussed further in Chapter 8, Notch are "Dual address" proteins, Gli when cleaved is a Transcription repressor, Transforming growth factor-β (TGF-β) is discussed further in Chapter 14, Patched when incapable of inhibiting Smoothened is an Oncoprotein, myc gene discussed further in Chapter 8, 150 target genes including IAP-2, 150 target genes including IAP-1, IκB kinase (IKK) phosphorylates Inhibitor of NF-κB (IκB), Notch binds as a ligand NotchL, 150 target genes including Bcl-2, "Dual address" proteins normally reside in Cytoplasm, Gli when whole is a Transcription factor, Proteolytic cleavage which is believed to be Irreversible, Notch when activated undergoes Proteolytic cleavage, Gli when overexpressed is an Oncoprotein