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This Concept Map, created with IHMC CmapTools, has information related to: Class discussion Chapter 5, Autocrine signaling when Feed forward, Cancer treatments might target p53, Integrins can be first "domino" or involved throughout formation of Cancer, Receptors include Frizzled, Paracrine signaling controls Integrins, HER-2 are Transmembrane proteins, Autocrine signaling is important in maintenance of Tissue architecture, Cells release from Extracellular matrix, Replication deficient virus into Tumor, Receptors are involved in Cell signaling, Mutations can occur in Regulation, Tyrosine kinases control Growth, Actin remodels to create Mobility, Clusters signal Endocytosis, Anchorage dependence is influenced by Ras, Growth factors are released in excessive amounts when there is an excess of Tyrosine kinases, Mutations can occur in Tyrosine kinases, Cell signaling to own cell is Autocrine signaling, Herceptin targets HER-2, Phosphotyrosine residues constitute 0.1-0.5% of Phosphoamino acids