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This Concept Map, created with IHMC CmapTools, has information related to: Chapter 6 Discussion Map, affinity decreases so it doesn't reactivate Ras, cells transduce signals, receptor in order to be more regulated, PIP2 can be phosphorylated, covalent modifications ex TKs, integrin activates PI3K, integrin are always dimers, PLC and give soluble IP3, phosphorylation pathways ex PI, SH3 binds hydrophobic prolines, receptor in order to respond to various signals, amino acid that can preferably lead to apoptosis and proliferation, Grb2 activates Ras, Sevenless is a receptor, SoS activates Grb2, ligand its affinity, Notch is not amplifying signals, Shc activates Grb2, divide if they maintain contact with ECM, TKs have enzymatic activity