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This Concept Map, created with IHMC CmapTools, has information related to: Section 7-8, promoter methylation is epigenetic, tumor suppresssor genes ex p16^INK4A, replication causes strands to be hemi- methylated, hemi- methylated are methylated by maintenance methylases, promoter methylation of RASSF1A, BRCA1 is discussed in Section 12.10, genes within tumor cell genomes, in situ measurements of DNA methylation, methylation of genes, MSP reaction gauges promoter methylation, p16^INK4A is described in Section 8.4, maintenance methylases ex BRCA1, promoter methylation inactivates tumor suppresssor genes