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This Concept Map, created with IHMC CmapTools, has information related to: Section 7-11, ubiquitylation tags cellular proteins, proteasomes make antigens, genetic mapping uses large kindreds, Apc helps egress cells, cells from colonic crypts, cellular proteins for destruction, human populations help detect familial cancer syndromes, immune system as discussed in Section 15.3, colonic crypts have high levels of β-catenin, human populations help isolate genes, antigens for the immune system, β-catenin associates with Tcf/ Lef, cellular proteins ex cyclins, β-catenin binds to E- cadherin, cyclins are discussed in Chapter 8, destruction in proteasomes, Apc downregulates β-catenin