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This Concept Map, created with IHMC CmapTools, has information related to: section 7-12, HIF- 1 activates expression of VEGF, HIF- 1 is degraded in normoxia, HIF- 1 causes angiogenesis, HIF- 1 is not degraded in hypoxia, tumors as discussed in Section 13.6, erythropoiesis important for tumors, HIF- 1 causes erythropoiesis, Von Hippel- Lindau disease includes hemangioblastomas, pVHL when defective can cause familial polycythemia, VEGF is discussed in Chapter 13, pVHL modulating the hypoxic response, angiogenesis important for tumors, Von Hippel- Lindau disease is characterised by pVHL, pVHL regulates HIF- 1