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This Concept Map, created with IHMC CmapTools, has information related to: Section 7.12, pVHL regulates and interacts with hypoxia-inducible factor-1, proteins for destruction by proteosomes, VEGF targets hypoxia-inducible factor-1, hypoxia in Von Hippel-Lindau disease, Familial polycythemia results in defects from VHL, ubiquitylation tags proteins, pVHL regulates the hypoxia