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This Concept Map, created with IHMC CmapTools, has information related to: Class discussion Chapter 6, concentration change eg beta-catenin, Kinase have opposite effects, important for Regulation, Effector loop gives the molecule preference for Raf, energy without nvolvement of Shc, transit activity includes Ras pathway, Signal transduction can occur by concentration change, SH3 domain binds to SOS, Tyrosine kinase receptors bind in Extracellular space, Effector loop gives the molecule preference for PI3K, Ras pathway didn't evolve as separate pathways due to low Selective pressure, Effector loop determined by Transcriptional control, cadherins bind to ECM, Prolines at Cryptic site, Signal transduction can occur by transit activity, ECM amount very low in Cancer cells, Frizzled activates Disheveled, Raf is a G protein, Ral-GEF activation controls Filipodia, beta-catenin attached to cadherins, Ral-GEF activation controls Lamellipodia