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This Concept Map, created with IHMC CmapTools, has information related to: Section 8.12, regulation from p15 ink4B, regulation from p16 ink4A, altered in a variety of tumors, D-CDK4/6 is composed of cyclin D1, D-CDK4/6 is composed of CDK4, D-CDK4/6 can receive point mutations, E-CDK2 hyperphosphorylates pRB, CDK4 or CDK6, cyclin D1 undergoes gene amplification, point mutations preventing regulation, pRB controls the R-point, deregulation of the cell cycle clock leads to tumors, p16 ink4A mutation is a mechanisms, mechanisms typically leading to deregulation of the cell cycle clock, D-CDK4/6 hypophosphorylates pRB, altered through a variety of mechanisms, pRB is often altered, p16 ink4A inhibits D-CDK4/6, point mutations that typically result in deregulation of the cell cycle clock, Skp2/Cul1 complex regulates the levels of p27 kip1