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This Concept Map, created with IHMC CmapTools, has information related to: Merge Ch8 sections 3, 6, 9, 12, CDKs complex to regulate the Cell cycle clock, D-CDK4/6 hypophosphorylates pRB, CDK4 or CDK6, CDK4 forming D-CDK4/6, pRB controls the R-point, bHLH transcription factors target genes with E-box sequences, altered in a variety of tumors, Myc oncoprotein complexes with other proteins, D-CDK4/6 is composed of CDK4, D-CDK4/6 hypophosphorylates pRB, phase G2 is part of the Cell cycle clock, p15 ink4B inhibits D-CDK4/6, E-CDK2 prepares proteins for the centrosome, A-CDC2 operates in phase G2, point mutations that typically result in deregulation of the cell cycle clock, CDK2 and form A-CDK2, E-CDK2 hyperphosphorylates pRB, deregulation of the cell cycle clock leads to tumors, D-cyclin bind CDK6, A-CDC2 sets up for phase M