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This Concept Map, created with IHMC CmapTools, has information related to: Chapter 8 concepts, myc is a transcription factor, cyclins are a core component of cell cycle clock, E2F transcription factors affect pRb, Akt/PKB in human breast cancers, quiescence decisions made during G1 phase, p27 Kip1 is suppresed by Skp2, p27 Kip1 is suppresed by Akt/PKB, tumor progression is discussed in chapter 11, cyclin-dependent kinases are a core component of cell cycle clock, cyclin-CDK complexes are regulated by CDK inhibitors, external signals influence active cell cycle, phosphorylated except when perturbed by myc, phosphorylated as controlled by various mitogenic signaling pathways, Restriction point transition can be controlled by mitogens, cell cycle clock is the central governor of growth, growth decisions made during G1 phase, phosphorylated except when perturbed by TGF-beta, p27 Kip1 is discussed in Section 9.9, CDK inhibitors eg TGF-beta, cell cycle clock is the central governor of proliferation