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This Concept Map, created with IHMC CmapTools, has information related to: Section 8.12, pRb function is perturbed in most human cancers, human tumors perturb transitions in the R point, human cancers lead to degregulation of cell cycle clock, molecular changes in human cancers, cyclin D gene is amplified in cancer cells, p27Kip1 levels are suppressed by Skp2