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This Concept Map, created with IHMC CmapTools, has information related to: Chapter 7, promoter methylation is reversible, promoter methylation resulting in inactivation, APC e.g. tumor suppressor genes, mutations may be dominant, promoter methylation is an epigenetic event, inactivation and cause papillomas, loss of heterozygosity (LOH) event e.g. nondisjunction, oncogenes are dominant, oncogenes e.g. Ras, promoter methylation is affected by de novo methylases, promoter methylation e.g. hypomethylation, tumor suppressor genes are recessive, tumor suppressor genes may have haploinsufficiency, somatic deletion results in neurofibromatosis, tumor suppressor genes control the cell cycle, loss of heterozygosity (LOH) event can cause inactivation, tumor suppressor genes must have mutations, VHL e.g. tumor suppressor genes, de novo methylases are classified as gatekeepers, epigenetic event as it does not modify the DNA sequence