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This Concept Map, created with IHMC CmapTools, has information related to: Section 9-8, E2F1 when elevated means loss of pRb control, ARF gene can be altered to eliminate ARF, immune system causes intentionally, p53 protect against cancer, E2F1 induces apoptosis, ARF monitor intracellular signaling, ARF protect against cancer, E2F1 required for the development of the immune system, ARF mediate apoptosis, p53 mediate apoptosis, intentionally hyperactivation of E2F1, p53 monitor intracellular signaling, E2F1 drives expression of caspases