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This Concept Map, created with IHMC CmapTools, has information related to: Section 9-13, apoptosis depends on mitochondria, loss of anchorage to ECM triggers anoikis, phosphorylation control BH-3 only proteins, apoptosome activates caspase 9, caspase 9 cleaves and activates procaspase 3, cytochrome c associates with Apaf-1 protein, bim antagonizes Bcl-2-like genes, apoptosis causes depolarization of outer mitochondrion membrane, transcription control BH-3 only proteins, caspaces for ubiquitinylation and degradation, channels in the outer mitochondrion membrane, Bcl-2-like genes control flow of cytochrome c, outer mitochondrion membrane can initiate apoptosis, executioner caspaces are caspaces, pro-apoptotic signals trigger apoptosis, intracellular localization control BH-3 only proteins, cytochrome c can flow through channels, bim is a cousin of Bcl-2-like genes, procaspase 3 activates apoptotic caspase cascade, apoptosis causes spill of cytochrome c