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This Concept Map, created with IHMC CmapTools, has information related to: Section 9.13-9.15, cell death may be carried out by necrosis, anti-apoptotic stategies e.g. NF-kappaB transcription factor activation, cytochrome c which gets released into the cytosol, apoptosis is lost in malignant human cells, Myc as described in Section 9.8, anoxia trigger apoptotic machinery, anti-apoptotic stategies e.g. Bax gene inactivation, tumor necrosis factor (TNF) proteins bind to death receptors, myc oncogene may be mitogenic, Bcl-2 has relatives Bak, death substrates and form apoptotic bodies, initiator caspases trigger onset of apoptosis, NF-kappaB transcription factor activation as described in Section 6.12, Bcl-2 has relatives Bax, Akt/PKB is anti-apoptotic, deregulation of pRb pathway trigger apoptotic machinery, Bcl-2 has relatives Bid, outer membrane of the mitochondria, anti-apoptotic stategies that affect expression of Mdm2, Bcl-2 has relatives Bax