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This Concept Map, created with IHMC CmapTools, has information related to: Chapter 8, p130 influence decision at R point, human cells may promote metastasis, cell differentiation occurs via differential gene expression, normal cells have isolated occurences of cell differentiation, adenovirus which frees E2F transcription factors, Cyclin-dependent kinases (CDKs) to form a CDK-cyclin complex, Myc/Max promotes advance of cell cycle, cycln E accumulates when passing R point, positive-feedback loop frees E2F transcription factors, TGF-beta inhibits cyclin D1, R point causing pRb, receptors of different types control cell cycle clock, cell cycle clock deregulation in yeast, extracellular signals e.g. TGF-beta, differential gene expression triggering biochemical events, yeast will not cancer, CDK inhibitors e.g. p27, Myc promotes advance of cell cycle, differential gene expression triggering no cell proliferation, phosphorylation which frees E2F transcription factors