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This Concept Map, created with IHMC CmapTools, has information related to: Chapter 12 Discussion Map, cisplatin activates repair enzymes, DNA replication mechanisms allow tissue organization, chromosome structure mistakes lead to cancer susceptibility syndromes, MLH1 are mutated in HNPCC, mismatch repair occurs after appearance of nicks, 5-methylC turns to T, error prone polymerase has a germ line alternative, nicks due to Okazaki fragments, repair enzymes are responsible for base-excision repair, repair enzymes are responsible for nucleotide-excision repair, endogenous biochemical processes ex 5-methylC, exogenous mutagens and their metabolites, mismatch repair mistakes lead to cancer susceptibility syndromes, DNA replication mechanisms errors threaten cell genomes, repair enzymes are responsible for mismatch repair, apoptosis allow tissue organization, MLH1 are responsible for mismatch repair, HNPCC shows rapid progression, T despite methylation's protective effect, MSH2 are responsible for mismatch repair